Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
TARGETMOL CHEMICALS INC CAMIZESTRANT TFA 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Camizestrant TFA (AZD-9833 TFA) is a potent and orally active antagonist of estrogen receptor (ER).
Medchemexpress LLC Flonoltinib TFA | 2928093-29-0 | 98.04% | 25 MG
Flonoltinib TFA is a potent and orally active dual JAK2/FLT3 inhibitor, demonstrating anti-cancer activity. It effectively inhibits JAK2, FLT3, JAK1, and JAK3, and has shown significant effects in both laboratory and animal studies.
- Potent dual JAK2/FLT3 inhibitor
- Exhibits anti-cancer activity
- Down-regulates p-FLT3 in a dose-dependent manner
- Induces apoptosis and G1/G0 cell cycle arrest in MV4-11 cells
- Shows significant antitumor effects in NOD/SCID mouse models
Medchemexpress LLC Ezm0414 Tfa | 2411759-92-5 | 95.5% | 514.51 | 25 MG
EZM0414 TFA is the trifluoroacetate salt form of EZM0414. It functions as a potent, selective, and orally active inhibitor of SETD2, making it suitable for research applications. This compound is being investigated for its potential in treating relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma.
- TFA salt form of EZM0414.
- Potent, selective, orally active SETD2 inhibitor.
- IC50 of 18 nM in biochemical assay.
- IC50 of 34 nM in cellular assay.
- Appearance is solid, white to light yellow.
- Store at 4°C, sealed, away from moisture.
- When in solvent, store at -80°C for 2 years or -20°C for 1 year, sealed and away from moisture.
Medchemexpress LLC Vasopressin-d5 (TFA) | 113-79-1 | 98.0% | 1 MG
Vasopressin-d5 TFA is the TFA salt form of Vasopressin-d5. It is an isotope-labeled compound of Vasopressin, a cyclic nonapeptide synthesized centrally in the hypothalamus. It participates in the hypothalamic-pituitary-adrenal axis, regulating pituitary corticotropin secretion by potentiating the stimulatory effects of the corticotropin-releasing factor. Vasopressin can also act as a neurotransmitter by binding to specific G protein-coupled receptors.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Achn-975 tfa | 1410809-37-8 | 99.0% | 483.44 | 1 ML
ACHN-975 TFA is a selective LpxC inhibitor that demonstrates subnanomolar LpxC inhibitory activity. It is effective against a broad spectrum of gram-negative bacteria, exhibiting low MIC values (≤1 μg/mL).
- Selective LpxC inhibitor.
- Exhibits subnanomolar LpxC inhibitory activity.
- Active against a wide range of gram-negative bacteria.
- Demonstrates low MIC values (≤1 μg/mL).
Medchemexpress LLC VTP-27999 (TFA) | 1013937-63-7 | 97.0% | C28H42ClF3N4O7 | 5 MG
VTP-27999 (TFA) is an alkyl amine Renin inhibitor useful for hypertension and end-organ diseases. This product is for research use only.
- Alkyl amine Renin inhibitor
- Useful for hypertension research
- Useful for end-organ diseases research
- For research use only
Medchemexpress LLC Mal-PEG2-NH2 TFA | 660843-23-2 | 99.4% | 342.27 | 50 MG
Mal-PEG2-NH2 (TFA) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting a ligand for an E3 ubiquitin ligase and a ligand for the target protein via a linker. The product appears as an oil, light yellow to yellow in color. This product is for research use only and not intended for patient use.
- PEG-based PROTAC linker.
- Used in the synthesis of PROTACs.
- Exploits the ubiquitin-proteasome system for selective protein degradation.
- Appears as an oil, light yellow to yellow in color.
Medchemexpress LLC Apstatin TFA | 99.4% | 25 MG
Apstatin TFA is a potent aminopeptidase P (APP) inhibitor. It exhibits Ki values of 2.6 μM for rat APP and 0.64 μM for human APP. This compound has also demonstrated cardioprotective effects.
- Potent aminopeptidase P (APP) inhibitor
- Effective at 2.6 μM for rat APP
- Effective at 0.64 μM for human APP
- Shows cardioprotection
- Reduces myocardial infarct size in acute myocardial ischemia models
- For research use only
Medchemexpress LLC Diprotin A TFA | 209248-71-5 | 99.6% | 455.47 | 50 MG
Diprotin A TFA (Ile-Pro-Ile TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV) for research use only. It increases the phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in human endothelial cells and disrupts endothelial cell-to-cell junctions. In in vivo models, it has been shown to increase retinal vascularity and leakage, and aggravate vascular leakage in diabetic retinopathy by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.
- Inhibits dipeptidyl peptidase IV (DPP-IV).
- Increases phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in human endothelial cells.
- Disrupts endothelial cell-to-cell junctions.
- Induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.
Medchemexpress LLC Relamorelin (TFA) | 2863659-22-5 | 99.8% | 905.00 | 100 MG
Relamorelin (RM-131) TFA, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a Ki of 0.42 nM for the GHS-1a receptor. It is centrally penetrant, increases growth hormone levels, and accelerates gastric emptying. Relamorelin TFA has potential for research into cachexia, gastroparesis, and gastric/intestinal dysmobility disorders.
- Selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist.
- Ki of 0.42 nM for GHS-1a receptor.
- Centrally penetrant.
- Increases growth hormone levels.
- Accelerates gastric emptying.
- Potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research.
- Purity: 99.81%.
Apexbio Technology LLC cyclo(RLsKDK) TFA(Synonyms: cyclo(RLsKDK), Cyclic peptide RLsKDK, ADAM8 inhibitor peptide, Cyclo-Arg-Leu-Ser-Lys-Asp-Lys), 5mg.
Cyclo(RLsKDK) TFA is a cyclic pentapeptide inhibitor targeting the metalloproteinase ADAM8 a transmembrane protein frequently dysregulated in pathological conditions such as inflammation cancer and neurodegenerative diseases By specifically inhibiting ADAM8 enzymatic activity cyclo(RLsKDK) TFA may modulate disease-associated cellular processes This molecule holds promise as a research tool for studying ADAM8 function and as a potential therapeutic candidate in inflammatory disorders and oncology
eMolecules 407-22-7 | 2-Fluoro-6-methylpyridine | Ambeed | MFCD00041226 | 111.119 | C6H6FN | 97.000 | Cc1cccc(F)n1 | 5g | 552650211
2-Fluoro-6-methylpyridine | Ambeed | 407-22-7 | MFCD00041226 | 111.119 | C6H6FN | 97.000 | Cc1cccc(F)n1 | 5g | 552650211
Apexbio Technology LLC GR 94800 TFA 5mg
GR 94800 TFA is a selective antagonist targeting neuropeptide Y (NPY) Y2 receptors Neuropeptide Y signaling via Y2 receptor subtypes participates in energy balance appetite modulation mood regulation anxiety-related behaviors and neuronal response to stress GR 94800 TFA specifically inhibits NPY Y2 receptor-mediated signaling thereby facilitating studies on the physiological and behavioral outcomes regulated by this receptor pathway It is commonly utilized by biomedical researchers investigating functions of NPY systems in feeding control emotional responses anxiety and depressive behaviors as well as cognition-related processes such as learning and memory Additionally this compound serves as an investigative tool to elucidate downstream signaling pathways and potential pharmacological targets linked to the Y2 receptor